Canine lymphomas are among the most common cancers diagnosed in dogs, however, it is more prevalent in Airedale Terriers, Basset Hounds, Boxers, Bulldogs, Golden Retrievers, Saint Bernard, and Scottish Terriers. Lymphoma is a type of cancer that originates in the lymphocyte cells of the immune system. Lymphocytes are a type of white blood cell that plays an integral role in the body’s defenses. Lymphomas may affect any organ in the body, but most commonly originate in lymph nodes before spreading to other organs such as the liver, spleen, and bone marrow.
Causes
Changes in the normal structure of chromosomes have been reported in canine lymphoma. Any of a group of viruses, many of which can cause tumors, and certain environmental factors are believed to trigger the disease. Some examples include indoor and outdoor chemicals, as well as exposure to magnetic fields. The causes are a compilation of factors and the exact cause is still unknown.
Types and Symptoms
The most common type of lymphoma found in dogs is multicentric lymphoma. The initial symptom in dogs is firm, enlarged, non-painful lymph nodes. A lymph node affected by lymphoma will feel like a hard, rubbery lump under your dog’s skin. Death occurs mostly due to organ failure. Lymphoma eventually invades the organs and the healthy tissues are replaced by the diseased ones. Weight loss, difficulty in breathing, extreme thirst, fever, and hemorrhaging are just a few of the symptoms. Central nervous system (CNS) lymphoma occurs due to the metastasis of multicentric lymphoma. Symptoms may vary from paralysis to seizures.
Cutaneous lymphoma first appears as dry, flaky, red, and itchy patches of skin. As the disease progresses, the skin becomes moist, ulcerated, very red, and thickened. Cutaneous lymphoma may be treated for several months as an infection or allergy by mistake before a diagnosis of lymphoma is made. Cutaneous lymphoma may also appear in the mouth, and is often mistaken for periodontal disease or gingivitis in its early stages.
Alimentary lymphoma occurs in the gastrointestinal tract of dogs. It can become fatal if the tumor is situated near the small or large intestine. Dogs with gastrointestinal lymphoma usually have symptoms such as vomiting, weight loss, and watery diarrhea. The diarrhea is often very dark in color and foul smelling.
Breathing difficulties typically develop with mediastinal lymphoma. This may be due to the accumulation of fluid within the chest, or from the presence of a large mass within the chest. Affected dogs may also show swelling of the face or front legs, as well as increased thirst and urination.
Extranodal lymphoma is the rarest among all lymphomas. It can affect areas like the skin, mouth, eyes, bone, liver, and breast tissue. Patients with extranodal lymphoma show degeneration of the organs involved.
Other symptoms are variable depending upon the location and stage of tumor, but generally, the symptoms that are most common in all forms of lymphoma are lack of appetite, weight loss, muscle weakness, and extreme lack of energy.
Diagnosis
You will need to give your veterinarian a thorough history of your dog’s health and full description of symptoms. Once the initial history has been taken, your veterinarian will perform a complete physical examination on your dog. Routine laboratory testing includes a biochemistry profile, and urinalysis, and a complete blood count. More specific testing may be required for a confirmatory diagnosis. The best way to diagnose lymphoma is to perform a biopsy. A biopsy is a minor surgical procedure to remove a piece of lymph node or other organ affected by cancer. Diagnostic imaging, including X-rays and ultrasound, are often used to evaluate the size of regional lymph nodes. Your veterinarian will also take bone marrow samples to be sent to a veterinary pathologist for further evaluation and to determine the extent of disease.
Treatment
The most effective therapy for most types of canine lymphoma is chemotherapy, but in some cases, surgery or radiation therapy may also be recommended. “Remission” means a regression of your dog’s cancer. Unfortunately, relapses are common after chemotherapy, and it is rarely found to have long term affect. Most dogs tolerate chemotherapy much better than humans typically do, and serious side effects are uncommon. The ultimate goal of chemotherapy is to improve the quality of life in affected patients. As of now, there is no cure being released for this disease.
Management
Regular checkups are required for evaluating the patient’s progress, along with regular blood testing, cardiac, and other body system evaluations. During chemotherapy, patients are more prone to various infections, so you will need to watch your dog for any signs of infection. Chemotherapy is also potentially hazardous for humans, therefore you should talk to the veterinary oncologist about safe handling and administration of chemotherapeutic medicines at home.